Potassium Channel Mutant KCNJ5 T158A Expression in HAC-15 Cells Increases Aldosterone Synthesis

Primary aldosteronism is the most common cause of secondary hypertension, most frequently due to an aldosterone-producing adenoma or idiopathic hyperaldosteronism. Somatic mutations of the potassium channel KCNJ5 in the region of the selectivity filter have been found in a significant number of aldo...

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Главные авторы: Oki, Kenji, Plonczynski, Maria W., Luis Lam, Milay, Gomez-Sanchez, Elise P., Gomez-Sanchez, Celso E.
Формат: Artigo
Язык:Inglês
Опубликовано: Endocrine Society 2012
Предметы:
Glucocorticoids-CRH-ACTH-Adrenal
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320257/
https://ncbi.nlm.nih.gov/pubmed/22315453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-1733
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