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Nongenomic Mechanisms of PTEN Regulation

A large amount of data supports the view that PTEN is a bona fide tumor suppressor gene. However, recent evidence suggests that derailment of cellular localization and expression levels of functional nonmutated PTEN is a determining force in inducing abnormal cellular and tissue outcomes. As the cel...

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Detalhes bibliográficos
Main Authors: Fata, Jimmie E., Debnath, Shawon, Jenkins, Edmund C., Fournier, Marcia V.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320059/
https://ncbi.nlm.nih.gov/pubmed/22536248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/379685
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