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Reduced Axonal Transport and Increased Excitotoxic Retinal Ganglion Cell Degeneration in Mice Transgenic for Human Mutant P301S Tau

The effects of tau hyperphosphorylation and aggregation on axonal transport were investigated in the optic nerve of mice transgenic for human mutant P301S tau. Transport was examined using cholera toxin B tracing. Retrograde transport was reduced in transgenic mice at 3 and 5 months of age, when com...

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Autori principali: Bull, Natalie D., Guidi, Alessandra, Goedert, Michel, Martin, Keith R., Spillantini, Maria Grazia
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319610/
https://ncbi.nlm.nih.gov/pubmed/22496848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034724
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