Differential Epigenetic Regulation of TOX Subfamily High Mobility Group Box Genes in Lung and Breast Cancers

Aberrant cytosine methylation affects regulation of hundreds of genes during cancer development. In this study, a novel aberrantly hypermethylated CpG island in cancer was discovered within the TOX2 promoter. TOX2 was unmethylated in normal cells but 28% lung (n = 190) and 23% breast (n = 80) tumors...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Tessema, Mathewos, Yingling, Christin M., Grimes, Marcie J., Thomas, Cynthia L., Liu, Yushi, Leng, Shuguang, Joste, Nancy, Belinsky, Steven A.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319602/
https://ncbi.nlm.nih.gov/pubmed/22496870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034850
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы