Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARɣ and LXRα pathways

RATIONALE: A crucial step in atherogenesis is the infiltration of the sub-endothelial space of large arteries by monocytes where they differentiate into macrophages and transform into lipid-loaded foam cells. Macrophages are heterogeneous cells which adapt their response to environmental cytokines....

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Hauptverfasser: Chinetti-Gbaguidi, Giulia, Baron, Morgane, Bouhlel, Mohamed Amine, Vanhoutte, Jonathan, Copin, Corinne, Sebti, Yasmine, Derudas, Bruno, Mayi, Thérèse, Bories, Gael, Tailleux, Anne, Haulon, Stéphane, Zawadzki, Christophe, Jude, Brigitte, Staels, Bart
Format: Artigo
Sprache:Inglês
Veröffentlicht: Lippincott Williams & Wilkins 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319502/
https://ncbi.nlm.nih.gov/pubmed/21350215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.110.233775
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