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Dynamin and PTP-PEST cooperatively regulate Pyk2 dephosphorylation in osteoclasts
Bone loss is caused by the dysregulated activity of osteoclasts which degrade the extracellular bone matrix. The tyrosine kinase Pyk2 is highly expressed in osteoclasts, and mice lacking Pyk2 exhibit an increase in bone mass, in part due to impairment of osteoclast function. Pyk2 is activated by pho...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3319480/ https://ncbi.nlm.nih.gov/pubmed/22342188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2012.01.022 |
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