Quantitation of Melatonin and N-acetylserotonin in Human Plasma by Nanoflow LC-MS/MS and Electrospray LC-MS/MS

Melatonin (MEL) and its chemical precursor N-acetylserotonin (NAS) are believed to be potential biomarkers for sleep-related disorders. Measurement of these compounds, however, has proven to be difficult due to their low circulating levels, especially that of NAS. Few methods offer the sensitivity,...

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Bibliographic Details
Main Authors: Carter, Melissa D., Calcutt, M. Wade, Malow, Beth A., Rose, Kristie L., Hachey, David L.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319463/
https://ncbi.nlm.nih.gov/pubmed/22431453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jms.2051
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