Estradiol Triggers Sonic-hedgehog–induced Angiogenesis During Peripheral Nerve Regeneration by Downregulating Hedgehog-interacting Protein

Both estradiol (E2) and Sonic Hedgehog (Shh) contribute to angiogenesis and nerve regeneration. Here, we investigated whether E2 improves the recovery of injured nerves by downregulating the Shh-inhibitor Hedgehog-interacting Protein (HIP) and increasing Shh-induced angiogenesis. Mice were treated w...

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Hauptverfasser: Sekiguchi, Haruki, Ii, Masaaki, Jujo, Kentaro, Renault, Marie-Ange, Thorne, Tina, Clarke, Trevor, Ito, Aiko, Tanaka, Toshikazu, Klyachko, Ekaterina, Tabata, Yasuhiko, Hagiwara, Nobuhisa, Losordo, Douglas W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319330/
https://ncbi.nlm.nih.gov/pubmed/22330336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2012.6
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