The region of XRCC1 which harbours the three most common nonsynonymous polymorphic variants, is essential for the scaffolding function of XRCC1

XRCC1 functions as a non-enzymatic, scaffold protein in single strand break repair (SSBR) and base excision repair (BER). Here, we examine different regions of XRCC1 for their contribution to the scaffolding functions of the protein. We found that the central BRCT1 domain is essential for recruitmen...

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Détails bibliographiques
Auteurs principaux: Hanssen-Bauer, Audun, Solvang-Garten, Karin, Gilljam, Karin Margaretha, Torseth, Kathrin, Wilson, David M., Akbari, Mansour, Otterlei, Marit
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319167/
https://ncbi.nlm.nih.gov/pubmed/22281126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2012.01.001
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