Establishing Rps6 hemizygous mice as a model for studying how ribosomal protein haploinsufficiency impairs erythropoiesis

Diamond-Blackfan Anemia(DBA) is a congenital hypoproliferative macrocytic anemia; 5q-syndrome myelodysplastic syndrome(MDS) is an acquired hypoproliferative macrocytic anemia. Their common erythroid phenotype reflects a shared pathophysiology -- haploinsufficiency of one of many ribosomal proteins a...

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Bibliografiske detaljer
Main Authors: Keel, Siobán, Phelps, Susan, Sabo, Kathleen, O’Leary, Monique N., Kirn-Safran, Catherine B., Abkowitz, Janis L.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319152/
https://ncbi.nlm.nih.gov/pubmed/22198155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2011.12.003
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