A Novel RhoA/ROCK-CPI-17-MEF2C Signaling Pathway Regulates Vascular Smooth Muscle Cell Gene Expression

Differentiation of vascular smooth muscle cells (VSMC) is a fundamental aspect of normal development and vascular disease. During contraction, VSMCs modulate calcium sensitivity through RhoA/ROCK-mediated inhibition of the myosin light chain phosphatase complex (MLCP). Previous studies have demonstr...

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Bibliographische Detailangaben
Hauptverfasser: Pagiatakis, Christina, Gordon, Joseph W., Ehyai, Saviz, McDermott, John C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Developmental Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318694/
https://ncbi.nlm.nih.gov/pubmed/22275376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.286203
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