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HIV Infection Abrogates the Functional Advantage of Natural Killer Cells Educated through KIR3DL1/HLA-Bw4 Interactions To Mediate Anti-HIV Antibody-Dependent Cellular Cytotoxicity

Combinations of KIR3DL1 and HLA-Bw4 alleles protect against HIV infection and/or disease progression. These combinations enhance NK cell responsiveness through the ontological process of education. However, educated KIR3DL1(+) NK cells do not have enhanced degranulation upon direct recognition of au...

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Detalhes bibliográficos
Main Authors: Parsons, Matthew S., Wren, Leia, Isitman, Gamze, Navis, Marjon, Stratov, Ivan, Bernard, Nicole F., Kent, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318670/
https://ncbi.nlm.nih.gov/pubmed/22345455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06112-11
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