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C7L Family of Poxvirus Host Range Genes Inhibits Antiviral Activities Induced by Type I Interferons and Interferon Regulatory Factor 1

Vaccinia virus (VACV) K1L and C7L function equivalently in many mammalian cells to support VACV replication and antagonize antiviral activities induced by type I interferons (IFNs). While K1L is limited to orthopoxviruses, genes that are homologous to C7L are found in diverse mammalian poxviruses. I...

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Detalhes bibliográficos
Main Authors: Meng, Xiangzhi, Schoggins, John, Rose, Lloyd, Cao, Jingxin, Ploss, Alexander, Rice, Charles M., Xiang, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318637/
https://ncbi.nlm.nih.gov/pubmed/22345458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06140-11
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