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Amino Acid Substitutions at Positions 122 and 145 of Hepatitis B Virus Surface Antigen (HBsAg) Determine the Antigenicity and Immunogenicity of HBsAg and Influence In Vivo HBsAg Clearance
A variety of amino acid substitutions, such as K122I and G145R, have been identified around or within the a determinant of hepatitis B surface antigen (HBsAg), impair HBsAg secretion and antibody binding, and may be responsible for immune escape in patients. In this study, we examined how different...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology
2012
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3318601/ https://ncbi.nlm.nih.gov/pubmed/22301154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06353-11 |
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