Amino Acid Substitutions at Positions 122 and 145 of Hepatitis B Virus Surface Antigen (HBsAg) Determine the Antigenicity and Immunogenicity of HBsAg and Influence In Vivo HBsAg Clearance

A variety of amino acid substitutions, such as K122I and G145R, have been identified around or within the a determinant of hepatitis B surface antigen (HBsAg), impair HBsAg secretion and antibody binding, and may be responsible for immune escape in patients. In this study, we examined how different...

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Main Authors: Wu, Chunchen, Deng, Wanyu, Deng, Liu, Cao, Liang, Qin, Bo, Li, Songxia, Wang, Yun, Pei, Rongjuan, Yang, Dongliang, Lu, Mengji, Chen, Xinwen
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2012
Fag:
Genetic Diversity and Evolution
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318601/
https://ncbi.nlm.nih.gov/pubmed/22301154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06353-11
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