Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance

Previous reports indicate that the expression and/or activity of the protein-tyrosine phosphatase (PTP) LAR are increased in insulin-responsive tissues of obese, insulin-resistant humans and rodents, but it is not known whether these alterations contribute to the pathogenesis of insulin resistance....

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Zabolotny, Janice M., Kim, Young-Bum, Peroni, Odile D., Kim, Jason K., Pani, Michael A., Boss, Olivier, Klaman, Lori D., Kamatkar, Shubhangi, Shulman, Gerald I., Kahn, Barbara B., Neel, Benjamin G.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2001
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33185/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11309481/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.071050398
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