Association between the Haptoglobin and Heme Oxygenase 1 Genetic Profiles and Soluble CD163 in Susceptibility to and Severity of Human Malaria

Intravascular hemolysis is a hallmark event in the immunopathology of malaria that results in increased systemic concentrations of free hemoglobin (Hb). The oxidation of Hb by free radicals causes the release of heme, which amplifies inflammation. To circumvent the detrimental effects of free heme,...

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Hlavní autoři: Mendonça, Vitor R. R., Luz, Nívea F., Santos, Nadja J. G., Borges, Valéria M., Gonçalves, Marilda S., Andrade, Bruno B., Barral-Netto, Manoel
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
Témata:
Host Response and Inflammation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318432/
https://ncbi.nlm.nih.gov/pubmed/22290142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.05933-11
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