SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis

SQ109, a 1,2-diamine related to ethambutol, is currently in clinical trials for the treatment of tuberculosis, but its mode of action remains unclear. Here, we demonstrate that SQ109 disrupts cell wall assembly, as evidenced by macromolecular incorporation assays and ultrastructural analyses. SQ109...

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Detalhes bibliográficos
Main Authors: Tahlan, Kapil, Wilson, Regina, Kastrinsky, David B., Arora, Kriti, Nair, Vinod, Fischer, Elizabeth, Barnes, S. Whitney, Walker, John R., Alland, David, Barry, Clifton E., Boshoff, Helena I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318387/
https://ncbi.nlm.nih.gov/pubmed/22252828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05708-11
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