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Analysis of Multiple Leptospira interrogans Serovar Canicola Vaccine Proteomes and Identification of LipL32 as a Biomarker for Potency

The current batch potency test for Leptospira interrogans serovar Canicola vaccines requires the use of a large number of hamsters and has severe effects (i.e., hepatic and renal failure resulting in death); while this vaccine is effective, a safer, cheaper, more ethical replacement is desired. The...

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Detalhes bibliográficos
Main Authors: Humphryes, P. C., Weeks, M. E., Gielbert, A., Thomson, G., Coldham, N. G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318284/
https://ncbi.nlm.nih.gov/pubmed/22323560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.05622-11
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