Transcutaneous Immunization with a Vibrio cholerae O1 Ogawa Synthetic Hexasaccharide Conjugate following Oral Whole-Cell Cholera Vaccination Boosts Vibriocidal Responses and Induces Protective Immunity in Mice

A shortcoming of currently available oral cholera vaccines is their induction of relatively short-term protection against cholera compared to that afforded by wild-type disease. We were interested in whether transcutaneous or subcutaneous boosting using a neoglycoconjugate vaccine made from a synthe...

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Autors principals: Tarique, A. A., Kalsy, A., Arifuzzaman, M., Rollins, S. M., Charles, R. C., Leung, D. T., Harris, J. B., LaRocque, R. C., Sheikh, A., Bhuiyan, M. S., Saksena, R., Clements, J. D., Calderwood, S. B., Qadri, F., Kováč, P., Ryan, E. T.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
Matèries:
Vaccines
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318280/
https://ncbi.nlm.nih.gov/pubmed/22357651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.05689-11
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