Release of mitochondrial apoptogenic factors and cell death are mediated by CK2 and NADPH oxidase

Activation of the NADPH oxidase subunit, NOX2, and increased oxidative stress are associated with neuronal death after cerebral ischemia and reperfusion. Inhibition of NOX2 by casein kinase 2 (CK2) leads to neuronal survival, but the mechanism is unknown. In this study, we show that in copper/zinc-s...

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Autores principales: Kim, Gab Seok, Jung, Joo Eun, Narasimhan, Purnima, Sakata, Hiroyuki, Yoshioka, Hideyuki, Song, Yun Seon, Okami, Nobuya, Chan, Pak H
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318149/
https://ncbi.nlm.nih.gov/pubmed/22146192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2011.176
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