Cerebral glutamine metabolism under hyperammonemia determined in vivo by localized (1)H and (15)N NMR spectroscopy

Brain glutamine synthetase (GS) is an integral part of the glutamate–glutamine cycle and occurs in the glial compartment. In vivo Magnetic Resonance Spectroscopy (MRS) allows noninvasive measurements of the concentrations and synthesis rates of metabolites. (15)N MRS is an alternative approach to (1...

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Detalhes bibliográficos
Main Authors: Cudalbu, Cristina, Lanz, Bernard, Duarte, João MN, Morgenthaler, Florence D, Pilloud, Yves, Mlynárik, Vladimir, Gruetter, Rolf
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318147/
https://ncbi.nlm.nih.gov/pubmed/22167234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2011.173
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