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Cerebral glutamine metabolism under hyperammonemia determined in vivo by localized (1)H and (15)N NMR spectroscopy

Brain glutamine synthetase (GS) is an integral part of the glutamate–glutamine cycle and occurs in the glial compartment. In vivo Magnetic Resonance Spectroscopy (MRS) allows noninvasive measurements of the concentrations and synthesis rates of metabolites. (15)N MRS is an alternative approach to (1...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Cudalbu, Cristina, Lanz, Bernard, Duarte, João MN, Morgenthaler, Florence D, Pilloud, Yves, Mlynárik, Vladimir, Gruetter, Rolf
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318147/
https://ncbi.nlm.nih.gov/pubmed/22167234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2011.173
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