Cerebral glutamine metabolism under hyperammonemia determined in vivo by localized (1)H and (15)N NMR spectroscopy

Brain glutamine synthetase (GS) is an integral part of the glutamate–glutamine cycle and occurs in the glial compartment. In vivo Magnetic Resonance Spectroscopy (MRS) allows noninvasive measurements of the concentrations and synthesis rates of metabolites. (15)N MRS is an alternative approach to (1...

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Главные авторы: Cudalbu, Cristina, Lanz, Bernard, Duarte, João MN, Morgenthaler, Florence D, Pilloud, Yves, Mlynárik, Vladimir, Gruetter, Rolf
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2012
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318147/
https://ncbi.nlm.nih.gov/pubmed/22167234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2011.173
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