Actin polymerization stabilizes α4β1 integrin anchors that mediate monocyte adhesion

Leukocytes arrested on inflamed endothelium via integrins are subjected to force imparted by flowing blood. How leukocytes respond to this force and resist detachment is poorly understood. Live-cell imaging with Lifeact-transfected U937 cells revealed that force triggers actin polymerization at upst...

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Autors principals: Rullo, Jacob, Becker, Henry, Hyduk, Sharon J., Wong, Janice C., Digby, Genevieve, Arora, Pamma D., Cano, Adrianet Puig, Hartwig, John, McCulloch, Christopher A., Cybulsky, Myron I.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2012
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3317807/
https://ncbi.nlm.nih.gov/pubmed/22472442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201107140
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