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Computational Prediction of Metabolism: Sites, Products, SAR, P450 Enzyme Dynamics, and Mechanisms

[Image: see text] Metabolism of xenobiotics remains a central challenge for the discovery and development of drugs, cosmetics, nutritional supplements, and agrochemicals. Metabolic transformations are frequently related to the incidence of toxic effects that may result from the emergence of reactive...

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Bibliografski detalji
Glavni autori: Kirchmair, Johannes, Williamson, Mark J., Tyzack, Jonathan D., Tan, Lu, Bond, Peter J., Bender, Andreas, Glen, Robert C.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2012
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3317594/
https://ncbi.nlm.nih.gov/pubmed/22339582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci200542m
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