γ-Secretase Inhibition of Murine Choroidal Neovascularization Is Associated with Reduction of Superoxide and Proinflammatory Cytokines

PURPOSE. This study aimed to determine whether upregulation of γ-secretase could inhibit laser-induced choroidal neovascularization (CNV) and if this was associated with a reduction in both oxidative stress and proinflammatory cytokines. METHODS. γ-Secretase, or its catalytic subunit presenilin 1 (P...

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Hauptverfasser: Qi, Xiaoping, Cai, Jun, Ruan, Qing, Liu, Li, Boye, Sanford L., Chen, Zhijuan, Hauswirth, William W., Ryals, Renee C., Shaw, Lynn, Caballero, Sergio, Grant, Maria B., Boulton, Michael E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Association for Research in Vision and Ophthalmology, Inc. 2012
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3317409/
https://ncbi.nlm.nih.gov/pubmed/22205609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.11-8728
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