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Effects of 5-fluorouracil/guanine wobble base pairs in Z-DNA: molecular and crystal structure of d(CGCGFG).

The chemotherapeutic agent 5-fluorouracil is a DNA base analogue which is known to incorporate into DNA in vivo. We have solved the structure of the oligonucleotide d(CGCGFG), where F is 5-fluorouracil (5FU). The DNA hexamer crystallizes in the Z-DNA conformation at two pH values with the 5FU formin...

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Autors principals: Coll, M, Saal, D, Frederick, C A, Aymami, J, Rich, A, Wang, A H
Format: Artigo
Idioma:Inglês
Publicat: 1989
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC331712/
https://ncbi.nlm.nih.gov/pubmed/2922276
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