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Effects of 5-fluorouracil/guanine wobble base pairs in Z-DNA: molecular and crystal structure of d(CGCGFG).

The chemotherapeutic agent 5-fluorouracil is a DNA base analogue which is known to incorporate into DNA in vivo. We have solved the structure of the oligonucleotide d(CGCGFG), where F is 5-fluorouracil (5FU). The DNA hexamer crystallizes in the Z-DNA conformation at two pH values with the 5FU formin...

詳細記述

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書誌詳細
主要な著者: Coll, M, Saal, D, Frederick, C A, Aymami, J, Rich, A, Wang, A H
フォーマット: Artigo
言語:Inglês
出版事項: 1989
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC331712/
https://ncbi.nlm.nih.gov/pubmed/2922276
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