Epigenetic changes in fetal hypothalamic energy regulating pathways are associated with maternal undernutrition and twinning

Undernutrition during pregnancy is implicated in the programming of offspring for the development of obesity and diabetes. We hypothesized that maternal programming causes epigenetic changes in fetal hypothalamic pathways regulating metabolism. This study used sheep to examine the effect of moderate...

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Hlavní autoři: Begum, Ghazala, Stevens, Adam, Smith, Emma Bolton, Connor, Kristin, Challis, John R. G., Bloomfield, Frank, White, Anne
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2012
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316895/
https://ncbi.nlm.nih.gov/pubmed/22223754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-198762
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