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The Abundance of Deleterious Polymorphisms in Humans
Here I show a gradual decline in the proportion of deleterious nonsynonymous SNPs (nSNPs) from tip to root of the human population tree. This study reveals that up to 48% of nSNPs specific to a single genome are deleterious in nature, which underscores the abundance of deleterious polymorphisms in h...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Genetics Society of America
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3316666/ https://ncbi.nlm.nih.gov/pubmed/22267501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.111.137893 |
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