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Allelic Ratios and the Mutational Landscape Reveal Biologically Significant Heterozygous SNVs
The issue of heterozygosity continues to be a challenge in the analysis of genome sequences. In this article, we describe the use of allele ratios to distinguish biologically significant single-nucleotide variants from background noise. An application of this approach is the identification of lethal...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Genetics Society of America
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3316639/ https://ncbi.nlm.nih.gov/pubmed/22267497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.111.137208 |
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