Allelic Ratios and the Mutational Landscape Reveal Biologically Significant Heterozygous SNVs

The issue of heterozygosity continues to be a challenge in the analysis of genome sequences. In this article, we describe the use of allele ratios to distinguish biologically significant single-nucleotide variants from background noise. An application of this approach is the identification of lethal...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Chu, Jeffrey S.-C., Johnsen, Robert C., Chua, Shu Yi, Tu, Domena, Dennison, Mark, Marra, Marco, Jones, Steven J. M., Baillie, David L., Rose, Ann M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Genetics Society of America 2012
Gaiak:
Investigations
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316639/
https://ncbi.nlm.nih.gov/pubmed/22267497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.111.137208
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