Unlike for Human Monocytes after LPS Activation, Release of TNF-α by THP-1 Cells Is Produced by a TACE Catalytically Different from Constitutive TACE

BACKGROUND: Tumor necrosis factor-alpha (TNF-α) is a pro-inflammatory cytokine today identified as a key mediator of several chronic inflammatory diseases. TNF-α, initially synthesized as a membrane-anchored precursor (pro-TNF-α), is processed by proteolytic cleavage to generate the secreted mature...

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Autori principali: Moreira-Tabaka, Helena, Peluso, Jean, Vonesch, Jean-Luc, Hentsch, Didier, Kessler, Pascal, Reimund, Jean-Marie, Dumont, Serge, Muller, Christian D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316627/
https://ncbi.nlm.nih.gov/pubmed/22479555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034184
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