Silencing of Renal DNaseI in Murine Lupus Nephritis Imposes Exposure of Large Chromatin Fragments and Activation of Toll Like Receptors and the Clec4e

Recent studies demonstrate that transformation of mild lupus nephritis into end-stage disease is imposed by silencing of renal DNaseI gene expression in (NZBxNZW)F1 mice. Down-regulation of DNaseI results in reduced chromatin fragmentation, and in deposition of extracellular chromatin-IgG complexes...

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Autores principales: Thiyagarajan, Dhivya, Fismen, Silje, Seredkina, Natalya, Jacobsen, Søren, Elung-Jensen, Thomas, Kamper, Anne-Lise, Fenton, Christopher Graham, Rekvig, Ole Petter, Mortensen, Elin Synnøve
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316608/
https://ncbi.nlm.nih.gov/pubmed/22479529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034080
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