Anti-dsDNA Antibodies Promote Initiation, and Acquired Loss of Renal Dnase1 Promotes Progression of Lupus Nephritis in Autoimmune (NZBxNZW)F1 Mice

BACKGROUND: Lupus nephritis is characterized by deposition of chromatin fragment-IgG complexes in the mesangial matrix and glomerular basement membranes (GBM). The latter defines end-stage disease. METHODOLOGY/PRINCIPALS: In the present study we determined the impact of antibodies to dsDNA, renal Dn...

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Detalhes bibliográficos
Main Authors: Fenton, Kristin, Fismen, Silje, Hedberg, Annica, Seredkina, Natalya, Fenton, Chris, Mortensen, Elin Synnøve, Rekvig, Ole Petter
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2793523/
https://ncbi.nlm.nih.gov/pubmed/20041189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008474
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