Membrane Docking Geometry of GRP1 PH Domain Bound to a Target Lipid Bilayer: An EPR Site-Directed Spin-Labeling and Relaxation Study

The second messenger lipid PIP(3) (phosphatidylinositol-3,4,5-trisphosphate) is generated by the lipid kinase PI3K (phosphoinositide-3-kinase) in the inner leaflet of the plasma membrane, where it regulates a broad array of cell processes by recruiting multiple signaling proteins containing PIP(3)-s...

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Detalhes bibliográficos
Main Authors: Chen, Huai-Chun, Ziemba, Brian P., Landgraf, Kyle E., Corbin, John A., Falke, Joseph J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316598/
https://ncbi.nlm.nih.gov/pubmed/22479423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033640
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