Granzyme B Cleaves Decorin, Biglycan and Soluble Betaglycan, Releasing Active Transforming Growth Factor-β1

OBJECTIVE: Granzyme B (GrB) is a pro-apoptotic serine protease that contributes to immune-mediated target cell apoptosis. However, during inflammation, GrB accumulates in the extracellular space, retains its activity, and is capable of cleaving extracellular matrix (ECM) proteins. Recent studies hav...

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Autores principales: Boivin, Wendy A., Shackleford, Marlo, Vanden Hoek, Amanda, Zhao, Hongyan, Hackett, Tillie L., Knight, Darryl A., Granville, David J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316562/
https://ncbi.nlm.nih.gov/pubmed/22479366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033163
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