Inflammation Aggravates Disease Severity in Marfan Syndrome Patients

BACKGROUND: Marfan syndrome (MFS) is a pleiotropic genetic disorder with major features in cardiovascular, ocular and skeletal systems, associated with large clinical variability. Numerous studies reveal an involvement of TGF-β signaling. However, the contribution of tissue inflammation is not addre...

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Main Authors: Radonic, Teodora, de Witte, Piet, Groenink, Maarten, de Waard, Vivian, Lutter, Rene, van Eijk, Marco, Jansen, Marnix, Timmermans, Janneke, Kempers, Marlies, Scholte, Arthur J., Hilhorst-Hofstee, Yvonne, van den Berg, Maarten P., van Tintelen, J. Peter, Pals, Gerard, Baars, Marieke J. H., Mulder, Barbara J. M., Zwinderman, Aeilko H.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316543/
https://ncbi.nlm.nih.gov/pubmed/22479353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032963
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