Leishmania amazonensis Arginase Compartmentalization in the Glycosome Is Important for Parasite Infectivity

In Leishmania, de novo polyamine synthesis is initiated by the cleavage of L-arginine to urea and L-ornithine by the action of arginase (ARG, E.C. 3.5.3.1). Previous studies in L. major and L. mexicana showed that ARG is essential for in vitro growth in the absence of polyamines and needed for full...

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Main Authors: da Silva, Maria Fernanda Laranjeira, Zampieri, Ricardo Andrade, Muxel, Sandra M., Beverley, Stephen M., Floeter-Winter, Lucile M.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316525/
https://ncbi.nlm.nih.gov/pubmed/22479507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034022
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