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3′-5′ Phosphoadenosine phosphate is an inhibitor of PARP-1 and a potential mediator of the lithium-dependent inhibition of PARP-1 in vivo

pAp (3′-5′ phosphoadenosine phosphate) is a by-product of sulfur and lipid metabolism and has been shown to have strong inhibitory properties on RNA catabolism. In the present paper we report a new target of pAp, PARP-1 [poly(ADP-ribose) polymerase 1], a key enzyme in the detection of DNA single-str...

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Main Authors: Toledano, Elie, Ogryzko, Vasily, Danchin, Antoine, Ladant, Daniel, Mechold, Undine
Format: Artigo
Jezik:Inglês
Izdano: Portland Press Ltd. 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316155/
https://ncbi.nlm.nih.gov/pubmed/22240080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20111057
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