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Is phosphoadenosine phosphate phosphatase a target of lithium’s therapeutic effect?
Lithium, which is approved for treating patients with bipolar disorder, is reported to inhibit 3′(2′)-phosphoadenosine-5′-phosphate (PAP) phosphatase activity. In yeast, deletion of PAP phosphatase results in elevated PAP levels and in inhibition of sulfation and of growth. The effect of lithium on...
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| Glavni autori: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2966591/ https://ncbi.nlm.nih.gov/pubmed/19756369 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00702-009-0298-6 |
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