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The structure of tryptophan 7-halogenase (PrnA) suggests a mechanism for regioselective chlorination
Chlorinated natural products include vancomycin and cryptophycin A. Their biosyntheses involves regioselective chlorination by flavin-dependent halogenases. We report the structural characterization of tryptophan 7-halogenase (PrnA), which regioselectively chlorinates tryptophan. Tryptophan and FAD...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3315827/ https://ncbi.nlm.nih.gov/pubmed/16195462 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1116510 |
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