Persistent Cell-Autonomous Circadian Oscillations in Fibroblasts Revealed by Six-Week Single-Cell Imaging of PER2::LUC Bioluminescence

Biological oscillators naturally exhibit stochastic fluctuations in period and amplitude due to the random nature of molecular reactions. Accurately measuring the precision of noisy oscillators and the heterogeneity in period and strength of rhythmicity across a population of cells requires single-c...

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Autors principals: Leise, Tanya L., Wang, Connie W., Gitis, Paula J., Welsh, David K.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315561/
https://ncbi.nlm.nih.gov/pubmed/22479387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033334
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