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Thermodynamic State Ensemble Models of cis-Regulation

A major goal in computational biology is to develop models that accurately predict a gene's expression from its surrounding regulatory DNA. Here we present one class of such models, thermodynamic state ensemble models. We describe the biochemical derivation of the thermodynamic framework in sim...

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Библиографические подробности
Главные авторы: Sherman, Marc S., Cohen, Barak A.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315449/
https://ncbi.nlm.nih.gov/pubmed/22479169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002407
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