GADD45α inhibition of DNMT1 dependent DNA methylation during homology directed DNA repair

In this work, we examine regulation of DNA methyltransferase 1 (DNMT1) by the DNA damage inducible protein, GADD45α. We used a system to induce homologous recombination (HR) at a unique double-strand DNA break in a GFP reporter in mammalian cells. After HR, the repaired DNA is hypermethylated in rec...

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Bibliographische Detailangaben
Hauptverfasser: Lee, Bongyong, Morano, Annalisa, Porcellini, Antonio, Muller, Mark T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2012
Schlagworte:
Gene Regulation, Chromatin and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315326/
https://ncbi.nlm.nih.gov/pubmed/22135303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1115
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