A pre-initiation complex at the 3′-end of genes drives antisense transcription independent of divergent sense transcription

The precise nature of antisense transcripts in eukaryotes such as Saccharomyces cerevisiae remains elusive. Here we show that the 3′ regions of genes possess a promoter architecture, including a pre-initiation complex (PIC), which mirrors that at the 5′ region and which is much more pronounced at ge...

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Main Authors: Murray, Struan C., Serra Barros, Ana, Brown, David A., Dudek, Peter, Ayling, Jonathan, Mellor, Jane
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Gene Regulation, Chromatin and Epigenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315312/
https://ncbi.nlm.nih.gov/pubmed/22123739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1121
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