A pre-initiation complex at the 3′-end of genes drives antisense transcription independent of divergent sense transcription

The precise nature of antisense transcripts in eukaryotes such as Saccharomyces cerevisiae remains elusive. Here we show that the 3′ regions of genes possess a promoter architecture, including a pre-initiation complex (PIC), which mirrors that at the 5′ region and which is much more pronounced at ge...

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Bibliographic Details
Main Authors: Murray, Struan C., Serra Barros, Ana, Brown, David A., Dudek, Peter, Ayling, Jonathan, Mellor, Jane
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
Subjects:
Gene Regulation, Chromatin and Epigenetics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315312/
https://ncbi.nlm.nih.gov/pubmed/22123739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1121
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