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The DNA helicase Pfh1 promotes fork merging at replication termination sites to ensure genome stability
Bidirectionally moving DNA replication forks merge at termination sites composed of accidental or programmed DNA–protein barriers. If merging fails, then regions of unreplicated DNA can result in the breakage of DNA during mitosis, which in turn can give rise to genome instability. Despite its impor...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3315120/ https://ncbi.nlm.nih.gov/pubmed/22426535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.184663.111 |
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