Ultrafine anaphase bridges, broken DNA and illegitimate recombination induced by a replication fork barrier

Most DNA double-strand breaks (DSBs) in S- and G2-phase cells are repaired accurately by Rad51-dependent sister chromatid recombination. However, a minority give rise to gross chromosome rearrangements (GCRs), which can result in disease/death. What determines whether a DSB is repaired accurately or...

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Detalhes bibliográficos
Main Authors: Sofueva, Sevil, Osman, Fekret, Lorenz, Alexander, Steinacher, Roland, Castagnetti, Stefania, Ledesma, Jennifer, Whitby, Matthew C.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3159475/
https://ncbi.nlm.nih.gov/pubmed/21576223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr340
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