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DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase

Replication forks encounter impediments as they move through the genome, including natural barriers due to stable protein complexes and highly transcribed genes. Unlike lesions generated by exogenous damage, natural barriers are encountered in every S phase. Like humans, Schizosaccharomyces pombe en...

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Detalhes bibliográficos
Main Authors: Sabouri, Nasim, McDonald, Karin R., Webb, Christopher J., Cristea, Ileana M., Zakian, Virginia A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315119/
https://ncbi.nlm.nih.gov/pubmed/22426534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.184697.111
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